General Information

  • ID:  hor004130
  • Uniprot ID:  B3A0I9
  • Protein name:  Pyrokinin-4
  • Gene name:  NA
  • Organism:  Tyrannophasma gladiator (Gladiator) (Heel-walker)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Tyrannophasma (genus), Mantophasmatodea incertae sedis, Mantophasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AELPQGLWVRPRL
  • Length:  13
  • Propeptide:  AELPQGLWVRPRL
  • Signal peptide:  NA
  • Modification:  T13 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004130_AF2.pdbhor004130_ESM.pdb

Physical Information

Mass: 174905 Formula: C71H115N21O17
Absent amino acids: CDFHIKMNSTY Common amino acids: L
pI: 10.4 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 6
Hydrophobicity: -23.85 Boman Index: -1831
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 120
Instability Index: 5956.15 Extinction Coefficient cystines: 5500
Absorbance 280nm: 458.33

Literature

  • PubMed ID:  22508719
  • Title:  Peptidomics-based phylogeny and biogeography of Mantophasmatodea (Hexapoda).